It took a while for my mum to warm to The Big Bang Theory because she felt the show was focused around mocking an autistic guy. I've never felt like that though.
I watched this film about Temple Grandin yesterday, I found the parts when she was treated badly because of her autism rough to watch.
What I find most annoying is when people make jokes based on incorrect knowledge. I'm the first to laugh at something genuinely witty based on factual knowledge, regardless of however controversial or sensitive the topic is
Stupid shit based on ignorance is just offensive